Merial is working cooperatively with the U.S. Environmental Protection Agency to understand EPA concerns and data on increases in adverse events reported for pets from application of spot-on products for flea and tick control.

Although the EPA has stated that it has noted a 'sharp increase' in the number of reported adverse events associated with the use of spot-on flea and tick control products, our records do not indicate that this is the case for FRONTLINE®. The number of adverse events reported per volume of sales has remained consistently low since the introduction of FRONTLINE in 1996. Over one billion doses of FRONTLINE have been sold, so there is extensive experience with the product in marketed use.

Merial has not yet seen EPA's data and was only notified of the agency action shortly before it was publically announced. We, along with other manufacturers, expect to meet with EPA in early May.

Merial's Pharmacovigilance Department analyzes and records all suspected adverse events reported to the company concerning FRONTLINE products and reports them to the EPA, consistent with federal law. Most reported events are not serious; these include mild skin irritation at the site of application, transient lethargy and vomiting. But, Merial's policy is to record and report even the most minor adverse event.

FRONTLINE products quickly kill fleas and ticks on dogs and cats and can help protect the health of pets. Fleas often cause pets to bite and scratch. In addition, fleas can cause flea allergy dermatitis and may be carriers of dangerous diseases. Ticks can also carry and transmit diseases, including Lyme disease, which can cause serious health problems in pets and people.

Pet owners can continue to trust FRONTLINE products for long-lasting and effective flea and tick control.

Natasha Joseph
678-638-3690
natasha.joseph@merial.com