ZACTRAN® (gamithromycin) for bovine respiratory disease (BRD) treatment and control in high-risk cattle1
The active ingredient in ZACTRAN, gamithromycin, is rapidly absorbed, rapidly and
extensively distributed in lung tissue, and persists at high levels in lung tissue
for an extended period.1,2*
* Clinical relevance has not been determined.
ZACTRAN is a novel subclass of macrolide with a structural difference.3 Administer prescription ZACTRAN subcutaneously (SC) at 2 mL/110 lbs. body weight (6 mg/kg).
Rapid response in 24 hours4
10-day treatment and control4,5
A real alternative for BRD
Indications1
ZACTRAN is indicated for the treatment of BRD associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni in beef and non-lactating dairy cattle.
ZACTRAN is also indicated for the control of respiratory disease in beef and non-lactating dairy cattle at high risk of developing BRD associated with M. haemolytica and P. multocida.
Clinical study results
- In field trials, cattle treated with ZACTRAN showed a rapid response and significant improvement in BRD clinical signs within 24 hours after treatment.4
- In field trials, ZACTRAN provided 10-day treatment and control of BRD from a single dose.4,5
IMPORTANT SAFETY INFORMATION: For use in cattle only. Do not treat cattle within 35 days of slaughter. Because a discard time in milk has not been established, do not use in female dairy cattle 20 months of age or older, or in calves to be processed for veal. The effects of ZACTRAN on bovine reproductive performance, pregnancy and lactation have not been determined.
1 ZACTRAN product label.
2 Huang RA, Letendre LT, Banav N, et al. Pharmacokinetics of gamithromycin
in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial
activity. J Vet Pharmacol Ther. 2010;33(3):227-237.
3 Giguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin
in plasma, pulmonary epithelial lining fluid, bronchoalveloar cells and lung tissue
in cattle. Am J Vet Res. 2011;72(3):326-330.
4 Sifferman RL, Wolff WA, Holste JE, et al. Field efficacy evaluation
of gamithromycin for treatment of bovine respiratory disease in cattle at feedlots.
Intern J Appl Res Vet Med. 2011;9(2):171-180.
5 Lechtenberg K, Daniels CS, Royer GC, et al. Field efficacy study of
gamithromycin for the control of bovine respiratory disease in cattle at high risk
of developing the disease. Intern J Appl Res Vet Med. 2011;9(2):189-197.
®ZACTRAN is a registered trademark, and ™"Because it's critical,
it's ZACTRAN" is a trademark of Merial Limited.
©2011 Merial Limited, Duluth, GA. All rights reserved.
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